Middle East respiratory syndrome: pathogenesis and therapeutic developments.
Identifieur interne : 000B10 ( Main/Exploration ); précédent : 000B09; suivant : 000B11Middle East respiratory syndrome: pathogenesis and therapeutic developments.
Auteurs : Hani Choudhry [Arabie saoudite] ; Muhammed A. Bakhrebah [Arabie saoudite] ; Wesam H. Abdulaal [Arabie saoudite] ; Mazin A. Zamzami [Arabie saoudite] ; Othman A. Baothman [Arabie saoudite] ; Mohammed A. Hassan [Arabie saoudite] ; Mustafa Zeyadi [Arabie saoudite] ; Nawal Helmi [Arabie saoudite] ; Faisal Alzahrani ; Ashraf Ali ; Mohammad Khalid Zakaria [Royaume-Uni] ; Mohammad Azhar Kamal [Arabie saoudite] ; Mohiuddin Khan Warsi [Royaume-Uni] ; Firoz Ahmed [Royaume-Uni] ; Mahmood Rasool [Arabie saoudite] ; Mohammad Sarwar JamalSource :
- Future virology [ 1746-0794 ] ; 2019.
Abstract
The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.
DOI: 10.2217/fvl-2018-0201
PubMed: 32201499
Affiliations:
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Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Helmi, Nawal" sort="Helmi, Nawal" uniqKey="Helmi N" first="Nawal" last="Helmi">Nawal Helmi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Alzahrani, Faisal" sort="Alzahrani, Faisal" uniqKey="Alzahrani F" first="Faisal" last="Alzahrani">Faisal Alzahrani</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Ali, Ashraf" sort="Ali, Ashraf" uniqKey="Ali A" first="Ashraf" last="Ali">Ashraf Ali</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Zakaria, Mohammad Khalid" sort="Zakaria, Mohammad Khalid" uniqKey="Zakaria M" first="Mohammad Khalid" last="Zakaria">Mohammad Khalid 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sortKey="Choudhry, Hani" sort="Choudhry, Hani" uniqKey="Choudhry H" first="Hani" last="Choudhry">Hani Choudhry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Bakhrebah, Muhammed A" sort="Bakhrebah, Muhammed A" uniqKey="Bakhrebah M" first="Muhammed A" last="Bakhrebah">Muhammed A. Bakhrebah</name><affiliation wicri:level="1"><nlm:affiliation>Life Science & environment Research Institute, National Center for Genome Technology, King Abdulaziz City for Science and Technology (KACST), Riyadh 12371, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Life Science & environment Research Institute, National Center for Genome Technology, King Abdulaziz City for Science and Technology (KACST), Riyadh 12371</wicri:regionArea><wicri:noRegion>Riyadh 12371</wicri:noRegion></affiliation></author><author><name sortKey="Abdulaal, Wesam H" sort="Abdulaal, Wesam H" uniqKey="Abdulaal W" first="Wesam H" last="Abdulaal">Wesam H. Abdulaal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Zamzami, Mazin A" sort="Zamzami, Mazin A" uniqKey="Zamzami M" first="Mazin A" last="Zamzami">Mazin A. Zamzami</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Baothman, Othman A" sort="Baothman, Othman A" uniqKey="Baothman O" first="Othman A" last="Baothman">Othman A. Baothman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Hassan, Mohammed A" sort="Hassan, Mohammed A" uniqKey="Hassan M" first="Mohammed A" last="Hassan">Mohammed A. Hassan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Zeyadi, Mustafa" sort="Zeyadi, Mustafa" uniqKey="Zeyadi M" first="Mustafa" last="Zeyadi">Mustafa Zeyadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Helmi, Nawal" sort="Helmi, Nawal" uniqKey="Helmi N" first="Nawal" last="Helmi">Nawal Helmi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Alzahrani, Faisal" sort="Alzahrani, Faisal" uniqKey="Alzahrani F" first="Faisal" last="Alzahrani">Faisal Alzahrani</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Ali, Ashraf" sort="Ali, Ashraf" uniqKey="Ali A" first="Ashraf" last="Ali">Ashraf Ali</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Zakaria, Mohammad Khalid" sort="Zakaria, Mohammad Khalid" uniqKey="Zakaria M" first="Mohammad Khalid" last="Zakaria">Mohammad Khalid Zakaria</name><affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Pirbright Institute, Ash Road, GU240NF, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Kamal, Mohammad Azhar" sort="Kamal, Mohammad Azhar" uniqKey="Kamal M" first="Mohammad Azhar" last="Kamal">Mohammad Azhar Kamal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Jeddah, Jeddah 23890, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biochemistry, University of Jeddah, Jeddah 23890</wicri:regionArea><wicri:noRegion>Jeddah 23890</wicri:noRegion></affiliation></author><author><name sortKey="Warsi, Mohiuddin Khan" sort="Warsi, Mohiuddin Khan" uniqKey="Warsi M" first="Mohiuddin Khan" last="Warsi">Mohiuddin Khan Warsi</name><affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Pirbright Institute, Ash Road, GU240NF, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Firoz" sort="Ahmed, Firoz" uniqKey="Ahmed F" first="Firoz" last="Ahmed">Firoz Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Ash Road, GU240NF, Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Pirbright Institute, Ash Road, GU240NF, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Rasool, Mahmood" sort="Rasool, Mahmood" uniqKey="Rasool M" first="Mahmood" last="Rasool">Mahmood Rasool</name><affiliation wicri:level="1"><nlm:affiliation>Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589</wicri:regionArea><wicri:noRegion>Jeddah 21589</wicri:noRegion></affiliation></author><author><name sortKey="Jamal, Mohammad Sarwar" sort="Jamal, Mohammad Sarwar" uniqKey="Jamal M" first="Mohammad Sarwar" last="Jamal">Mohammad Sarwar Jamal</name><affiliation><nlm:affiliation>Hematology Lab Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.</nlm:affiliation><wicri:noCountry code="subField"> Saudi Arabia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Future virology</title><idno type="ISSN">1746-0794</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment. A large amount of information is now available regarding the virus, its structure, route of transmission and its pathophysiology. Therefore, this review summarizes the current understanding of MERS-CoV's pathogenesis, treatment options and recent scientific advancements in vaccine and other therapeutic developments, and the major steps taken for MERS prevention control.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Ali, Ashraf" sort="Ali, Ashraf" uniqKey="Ali A" first="Ashraf" last="Ali">Ashraf Ali</name><name sortKey="Alzahrani, Faisal" sort="Alzahrani, Faisal" uniqKey="Alzahrani F" first="Faisal" last="Alzahrani">Faisal Alzahrani</name><name sortKey="Jamal, Mohammad Sarwar" sort="Jamal, Mohammad Sarwar" uniqKey="Jamal M" first="Mohammad Sarwar" last="Jamal">Mohammad Sarwar Jamal</name></noCountry><country name="Arabie saoudite"><noRegion><name sortKey="Choudhry, Hani" sort="Choudhry, Hani" uniqKey="Choudhry H" first="Hani" last="Choudhry">Hani Choudhry</name></noRegion><name sortKey="Abdulaal, Wesam H" sort="Abdulaal, Wesam H" uniqKey="Abdulaal W" first="Wesam H" last="Abdulaal">Wesam H. Abdulaal</name><name sortKey="Bakhrebah, Muhammed A" sort="Bakhrebah, Muhammed A" uniqKey="Bakhrebah M" first="Muhammed A" last="Bakhrebah">Muhammed A. Bakhrebah</name><name sortKey="Baothman, Othman A" sort="Baothman, Othman A" uniqKey="Baothman O" first="Othman A" last="Baothman">Othman A. Baothman</name><name sortKey="Hassan, Mohammed A" sort="Hassan, Mohammed A" uniqKey="Hassan M" first="Mohammed A" last="Hassan">Mohammed A. Hassan</name><name sortKey="Helmi, Nawal" sort="Helmi, Nawal" uniqKey="Helmi N" first="Nawal" last="Helmi">Nawal Helmi</name><name sortKey="Kamal, Mohammad Azhar" sort="Kamal, Mohammad Azhar" uniqKey="Kamal M" first="Mohammad Azhar" last="Kamal">Mohammad Azhar Kamal</name><name sortKey="Rasool, Mahmood" sort="Rasool, Mahmood" uniqKey="Rasool M" first="Mahmood" last="Rasool">Mahmood Rasool</name><name sortKey="Zamzami, Mazin A" sort="Zamzami, Mazin A" uniqKey="Zamzami M" first="Mazin A" last="Zamzami">Mazin A. Zamzami</name><name sortKey="Zeyadi, Mustafa" sort="Zeyadi, Mustafa" uniqKey="Zeyadi M" first="Mustafa" last="Zeyadi">Mustafa Zeyadi</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Zakaria, Mohammad Khalid" sort="Zakaria, Mohammad Khalid" uniqKey="Zakaria M" first="Mohammad Khalid" last="Zakaria">Mohammad Khalid Zakaria</name></noRegion><name sortKey="Ahmed, Firoz" sort="Ahmed, Firoz" uniqKey="Ahmed F" first="Firoz" last="Ahmed">Firoz Ahmed</name><name sortKey="Warsi, Mohiuddin Khan" sort="Warsi, Mohiuddin Khan" uniqKey="Warsi M" first="Mohiuddin Khan" last="Warsi">Mohiuddin Khan Warsi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B10 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B10 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32201499
|texte= Middle East respiratory syndrome: pathogenesis and therapeutic developments.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32201499" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |